This post was originally published on this siteA study of more than 100,000 surgical cases at University of Virginia Health System found patients’ pain scores improved even as doctors gave fewer opioids. UVA anesthesiologists reviewed 101,484 surgeries between March 2011 and November 2015 where patients received general anesthesia. During that timeframe, the average amount of
Key signaling protein associated with addiction controls the actions of oxycodone in pain-free, chronic pain states
This post was originally published on this siteRGS9-2, a key signaling protein in the brain known to play a critical role in the development of addiction-related behaviors, acts as a positive modulator of oxycodone reward in both pain-free and chronic pain states, according to a study conducted at the Icahn School of Medicine at Mount
This post was originally published on this siteOpioids are the most powerful painkillers. Researchers at the Charité — Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells. These findings represent
This post was originally published on this siteFewer veterans received prescriptions for risky dosages of opioid painkillers after a national initiative took aim at reducing high doses and potentially dangerous drug combinations, a new study finds. Over a two-year period, high-dose opioid prescribing declined by 16 percent, and very-high-dose opioid prescribing dropped by 24 percent.